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Another study that combined whole blood transcriptome and serum metabolite analysis also demonstrated that serine and its metabolic pathway are negatively correlated with exposure to air pollutants such as PM2.5 and NO 2 with childhood asthma history ( 3.2.5 Lung related cancer In addition to participating in the bodys metabolic network, the L-serine metabolic network is often hijacked by tumors to promote cancer cell proliferation