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154 The relatively low mechanical stress (about 45 Pa) derived by the ECM can stimulate the stem cell signaling pathway via the cytoskeleton/AIRE axis by activating the integrin beta 1/3 receptor, while excessive mechanical stress (~450 Pa) induces quiescence in BCSCs dependent on DDR2/STAT1/P27 signaling, which may explain conflicting results observed in previous individual studies

Milanini et al, 2022)

Boutet A, Madhavan R, Elias GJ, Joel SE, Gramer R, Ranjan M, et al

If you could bottle up a plant-based prescription, it would become a blockbuster drug overnight, commented paper co-author Susan Levin, of the Physicians Committee for Responsible Medicine in Washington, D.C

(1988) reported cancer bioassays after inhalation exposure of Sprague-Dawley rats and Swiss and B6C3F 1 mice to trichloroethylene (see Table 3-3)