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The heterogeneity of lung cancer has an impact on the understanding of pathogenesis, diagnosis, molecular diagnostic tissue selection and treatment decision-making

Incomplete responses to systemic therapies might reflect the coexistence of several distinct populations of resistant cancer cells, including dormant tumour cells, cancer stem cells, clones harbouring primary resistance and DTPs

Catabolism of N-glycoproteins in mammalian cells: molecular mechanisms and genetic disorders related to the processes

J.1995The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

Another consideration is whether to target intracellular or extracellular (secreted) expression

On the other hand, ROS may seriously fry cells when their levels climb abruptly, which is known as oxidative stress (Yang and Lian, 2020)