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While FOXO proteins are often considered tumour suppressors (Paik et al, 2007

Upon activation by microbial PAMPs and other stress-related molecules, NLRP3 leads to the activation of caspase-1 followed by cleavage of pro-IL-1 into its active IL- form, which promotes further inflammatory signaling

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However, increased GSNO levels have been observed in inflammatory states and subsequent induction of inducible nitric oxide synthase (iNOS), which is also related to hypertension (32)

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