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Acknowledgements We thank for the fundings provided by the National Natural Science Foundation of China, Shandong Provincial Natural Science Foundation and Qingdao City Science and Technology Plan Park Incubation Project

10.1073/pnas.89.23.11533 227 WangJ.ChenC.ZhouJ.YeL.LiY.XuL.et al (2023)

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Grape Seed Extract: Perhaps, the most powerful and strengthening of all antioxidants is Grape Seed Extract

Most of the research in these areas comes from in vitro or animal studies, and there are no high-quality clinical trials consistently showing cosmetic or lifespan-extending effects in people.33 34 66 A few small studies suggest topical ALA may offer modest benefits for skin appearance, but these findings are early and so far dont apply to oral supplementation.35 Youre using ALA for weight loss You take certain medications ALA can interact with several medications.39 These include drugs for diabetes (like insulin or metformin), thyroid medications (like levothyroxine), and certain chemotherapy agents such as alkylating agents and antitumor antibiotics

Selenium supplementation can be beneficial but must be approached with caution due to potential adverse effects from excessive intake, including increased risks for certain chronic diseases and toxicity symptoms