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Following endogenous growth hormone release, insulin-like growth factor-1 (IGF-1) mediates many downstream physiological processes involved in normal growth hormone biology

A secretagogue nudges an upstream node and lets physiology set the resulting IGF-1 level within feedback limits

71 Interestingly, metabolite profiling of cells treated with Cu ionophore presents a time-dependent increase in the dysregulation of many TCA cycle-associated metabolites, and inhibiting the electron transport chain complexes I and II significantly reduced Cu-induced cell death

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