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Research dating back to the early 2000s has demonstrated that estradiol can activate mast cells through a non-genomic estrogen receptor alpha pathway and trigger calcium influx, leading to degranulation and release of histamine, tryptase, prostaglandins, leukotrienes, and inflammatory cytokines

Besides the genetic factors, environmental factors such as diet, lifestyle, obesity, and chronic stress are involved in migraine pathogenesis (710)

Ferritinophagy releases redox-inactive ferric iron, which is then converted to redox-active ferrous iron by accepting an electron from radical compounds and results in lipid peroxidation

Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase

Indeed, cognitive impairment is the single most reported complaint by patients with post-COVID syndrome [11,12,13]

Altomonte, J