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Zhang Y, Huang X, Liu N, Liu M, Sun C, Qi B, et al

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

SIRT3 is also believed as a protection for cardiomyocytes from oxidative stress-mediated cell damage (38)

One study found people with obesity who had higher levels of glutathione lost more weight when they followed a healthy eating plan for 6 months

On the other hand, IL-1 can feedback-stimulate NADPH oxidase, further exacerbating oxidative stress ( 3.2 Oxidative stress and metabolic dysregulation Mitochondrial dysfunction mediated by the SIRT1/NAD + pathway represents a pivotal mechanism in DN pathogenesis, where oxidative stress emerges as a central driver

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