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The sustained inhibitory effect of hAAT and of hAAT OX on TNF, for example, may be the result of targeting several planes in the TNF pathway, including some unrelated to protease inhibition, as in the case of the direct binding to TNF receptor subunit 74

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Simultaneously, inflammatory markers including lactoferrin, IL-8, and IL-1 were correspondingly reduced, further confirming the systemic anti-inflammatory effects of DPP1 inhibition

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In summary, while nutraceuticals represent a valuable tool in promoting health and preventing disease, their full potential can only be realized through rigorous scientific research, personalized dosing strategies, and a comprehensive understanding of both their benefits and potential risks