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The development of drug resistance has been documented in several regions globally, due to the overuse of PZQ, rate of parasitic mutation, poor treatment compliance, co-infection with different strains of schistosomes and the overall parasite load

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[DOI] [PubMed] [Google Scholar] 38.Liu J, Li M, Yu Y, Cao S

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In phase II metabolism, both curcumin and its reduced metabolites can be conjugated with glucuronic acid and sulfate at the phenolic site [18,19]

But because Rifaximin on its own has low success for methane SIBO and we dont want to permanently damage the gut with Neomycin, antibiotics definitely arent our preference for first line treatment