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In addition to its potentials on activating cellular antioxidant defense system, black cumin can directly scavenge free radicals, as demonstrated in several in vitro chemical assays like DPPH assay [35,292,293,294]

for instance, the relative levels of beta-alanyl-L-arginine, L-glutamic acid, and L-valine were significantly increased, whereas those of L-tryptophan, L-leucine, L-isoleucine, L-tyrosine, L-phenylalanine, and cis-4-hydroxy-D-proline were significantly reduced in MS-affected patients compared with those in healthy subjects

Pediatrics 25:7279 Duan AR, Jonasson EM, Alberico EO, Li C, Scripture JP, Miller RA, Alber MS, Goodson HV (2017) Interactions between Tau and different conformations of tubulin: implications for tau function and mechanism

The 1:2,500 ratio, however, shows superior efficacy, outperforming the alternatives up to the highest dose

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Galunisertib plus neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: a single-arm, phase 2 trial