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Description

Biological predictors of antidepressant treatment outcome

By elucidating the essential stress mitigation pathways that facilitate the survival of DTP cells during treatment, we discuss the potential treatment strategies to target DTP cells for durable cure of hematopoietic malignancies

[Abstract] EMBO Rep

415 The potential mechanism underlying this synergy is that D-pen upregulates the copper transport proteins hCtr1 and ATP7A, which share a transport system with platinum, 416 thereby increasing intracellular platinum levels