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Directions for Use Prime pen before first use Standard dose per injection: 250500 mcg (0.250.5 mg) (most common effective range for tissue repair studies) 250 mcg (0.25 mg): 6 clicks (0.25 0.0417 6) 500 mcg (0.5 mg): 12 clicks (0.5 0.0417 12) Frequency: 12 times daily (e.g., morning and evening