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Impairment of mismatch repair, homologous recombination deficiencies associated with BRCA1/2 loss, polymerase proofreading defects (e.g., POLE mutations), and carcinogenic insults such as tobacco smoke, ultraviolet radiation, and prior chemotherapy collectively accelerate mutation accumulation and diversify tumor cell populations (6668)

Gohil KJ, Patel JA (2010) A review on Bacopa monniera: current research and future prospects Int J Green Pharm 4 Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K (2010) Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimers disease model