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Authors contributions Participated in research design: Robey RW, Ambudkar SV, Gottesman MM Conducted experiments: Frye WJE, Huff LM, Gonzlez Dalmasy JM, Salazar P, Carter RM, Gensler RT, Robey RW Contributed new reagents or analytic tools: Esposito D Performed data analysis: Frye WJE, Huff LM, Gonzlez Dalmasy JM, Salazar P, Carter RM, Gensler RT, Robey RW Wrote or contributed to the writing of the manuscript: Frye WJE, Huff LM, Salazar P, Robey RW, Ambudkar SV, Gottesman MM Availability of data and materials The authors declare that all the data supporting the findings of this study are available within the paper and its Supplemental Data