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These include GSH inhibition of sulphate uptake and assimilation through effects on specic transporters and enzymes such as ATP sulphurylase 1 (APS1) and APR (Herschbach & Rennenberg 1994

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In striking contrast, in ONP-302 treated mice, tumors had large areas of necrosis ( Figure 6B ) supporting tumor tissue destruction by ONP-302 mediated effects

If a significant blood dyscrasia or jaundice occurs, specific therapy should be instituted for these complications

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Subsequently, they were lysed in RIP lysis buffer with added protease and RNase inhibitors