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10.1016/j.cmet.2023.12.007 [DOI] [PubMed] [Google Scholar] Guo J, Huang X, Dou L, Yan M, Shen T, Tang W, Li J (2022) Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

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In the brain, in order to induce tau phosphorylation, oxidative stress can directly interact with protein kinases, particularly glycogen synthase kinase-3 (GSK 3), increasing GSK-3 activity, which subsequently further disrupts its ability to bind to microtubules, accelerating their depolymerisation and interrupting neural signalling (48)