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Similarly, brown adipose cells, already primed for thermogenesis, might respond to AOD9604 with a pronounced spike in energy expenditure

MASH/NAFLD: Given the liver fat-reducing effects of GLP-1 receptor agonism, orforglipron may be evaluated for metabolic dysfunction-associated steatohepatitis (MASH), a condition affecting an estimated 5-6% of the adult population for which effective oral therapies are urgently needed

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