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However, simple crossing of the SOD1G93A mice with mice overexpressing EAAT2 (to about a double of the normal level) resulted in an ALS model where the appearance of ALS signs and the onset of the motor neuron loss were only marginally delayed, with no effect on the final outcome [392]

This effect was linked to increased free intracellular Zn 2+ that was not bound to MT3 and led to the downregulation of ROS production by increasing the expression of NRF2, HO-1, and CAT

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Its found in nearly every cell and plays a central role in antioxidant protection and cellular defense

Front Immunol (2021) 12:679973

Peptide therapy helps restore those signals so your body can start working the way its supposed to again