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It should be clarified that although the contribution of immune cells to metabolic diseases is mainly concentrated in AT, an effective source of such inflammation also exists in the liver, intestines, and other metabolic regulatory tissues, promoting the production of inflammation and obesity throughout the body through the circulation (131)

doi: 10.1038/s41569-019-0260-8 25 ChengGCaoZXuXvan MeirEGLambethJD

For example, TET1 levels are decreased in the eutopic endometrium of infertile women with endometriosis, contributing to dysregulated DNA methylation patterns

That is the same year the US was just beginning its own restriction fight

The data were loaded in R using the Seurat software package