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Remove the vial from the refrigerator and let it sit at room temperature for 15 to 20 minutes before trying again

Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, et al

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HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use

More importantly, very few patients discontinued treatment due to side effects, with rates below 5% in all groups ( Common adverse events reflected the studys conduct during the COVID-19 pandemic and typical respiratory symptoms seen in bronchiectasis patients, including COVID-19 infections, nasopharyngitis, cough, and headache