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Description

B.JasonD

Fe3+ iron ions must first be reduced to Fe2+ by cytochrome b reductase or other reductases at the brush border membrane [231, 232] and by food components acting as reducing agents before being transported into enterocytes by the divalent metal transporter 1 [233]

A proportion of relapses (10%) may occur beyond 20 years of onset of treatment [32]

Patients often value outcomes that are not fully captured by traditional clinical endpoints, such as fatigue, daily functioning, emotional well-being, treatment burden, and quality of life