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New blood vessel growth serves healing purposes, but uncontrolled angiogenesis has implications for conditions involving abnormal vascular proliferation

As mentioned previously, the optic nerve can be damaged by B12 deficiency

One patient developed an episode of seizure who received HBOT

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RCTs are generally stronger for testing causality, whereas cohort studies are better suited to studying long-term risk factors, natural disease progression, and situations where RCTs would be unethical or impractical