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Nonetheless, according to the available clinical evidence, adherence to a low-histamine diet has been reported to be effective in reducing gastrointestinal, dermatological, and neurological symptoms [8,21,67]

Ascites and peripheral edema are observed with the development of biliary cirrhosis and portal hypertension (see Chapter 70A)

Serotonin syndrome can be life-threatening if left untreated

The clinical titration starts at 0.25 mg weekly and increases every four weeks up to a maintenance dose of 2.4 mg weekly, though some research protocols extend up to 4.5 mg

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It acts as a mediator that converts these harmful elements into water-soluble forms and thus enables them to be excreted via the kidneys