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In a 2-year trial, acute pancreatitis was reported in 8 semaglutide-treated patients (0.27 cases per 100 patient-years) and 10 placebo-treated patients (0.33 cases per 100 patient-years), both on a background of standard of care.1 In trials of patients receiving oral semaglutide, pancreatitis was reported as a serious adverse event in 6 patients (0.1 events per 100 patient-years) receiving semaglutide versus 1 in comparator-treated patients (less than 0.1 events per 100 patient-years)

' But the benefits scientists found were so small that they would barely be noticeable over a 10-year period

doi: 10.1093/qjmed/hcaf108 187 AndreuxPABlanco-BoseBRyuDBurdetFIbbersonMAebischerPet al

For instance if 100mg is prescribed to you and you have a concentration of 200mg/mL in a 1.0 mL vial, the volume you take will be 0.5mL or cc as marked on the syringe

STEP 3 Add your water volume The volume of water you add affects the concentration of the peptide solution

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