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Several factors, including hypoxia, overload of all-transetinal (atRAL), high intraocular pressure, aging, and iron metabolism imbalance, lead to abnormal accumulation of iron in cells and retinas by affecting the proteins involved in the iron metabolism and homeostasis (Ugarte et al., 2013

doi: 10.1016/S0021-9258(18)97742-2 48 RheeSGChaeHZKimK

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When taken orally, EGCg is highly unstable in the alkaline environment of the small intestine and undergoes rapid first-pass metabolism in the liver

PMID: 11103316