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While untreated cardiomyocytes appeared filamentous and evenly distributed, PE treatment was associated with significant increases in cell size and increasingly irregular morphological characteristics, thus reaffirming the ability of PE to reliably induce cardiac hypertrophy

Many of these substances were designated as Category 2 substances on the FDAs interim 503A Bulks List in 2023, reflecting the FDAs preliminary determination that they presented significant safety risks in the context of compounding

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