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Poria acid (PA) upregulated the expression of GPX4, SLC7A11, and HO-1 by increasing the level of GSH and activating NRF2 in a mouse IRI-AKI model, which inhibited the induction of ferroptosis and attenuated AKI [8, 110]

380 By conjugating sialylated units to bivalent and trivalent scaffolds, the resulting inhibitors exhibited greatly enhanced inhibition (up to 428-fold) in multiple trials (Fig