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doi: 10.3389/fmolb.2021.765970 Received 27 August 2021 Accepted 01 November 2021 Published 22 November 2021 Volume 8 - 2021 Edited by Marc Diederich, Seoul National University, South Korea Reviewed by Dan Herschlag, Stanford University, United States Adrian Drazic, University of Bergen, Norway Updates Copyright 2021 Mannervik, Ismail, Lindstrm, Sjdin and Ing

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2006) and compromises the resistance of cultured murine astrocytes toward the damage induced by oxidative stress, xenobiotics or toxic metals (Table 1)

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Acyl-CoA synthetase long-chain family member 4 (ACSL4) thioesterifies arachidonic acid (AA) or adrenic acid (ADA) in PUFA-related phospholipids into PUFACoA [47], which is then esterified by lysophosphatidylcholine acyltransferase 3 (LPCAT3) into phospholipid polyunsaturated fatty acids (PUFAPL) [48]