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Crosslinking density and polymer chemical structures can modulate the stiffness of the final nanocarrier affecting the BBB crossing efficiency and intracellular accumulation of the cargo: as an example, Zheng et al., 2021) demonstrated that lower elasticity of PEG-block-poly(pentafluorophenyl methacrylate) NPs led to increased transcytosis and brain accumulation, despite shorter blood circulation times

Volcano plots showing significant acetylation sites for C4 and C8 separated by localization of genes

Cai C, Ma H, Peng J, Shen X, Zhen X, Yu C, et al

I.AytonS.Alzheimers Disease Neuroimaging Initiative (2019)

Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, P53, and Bax and Downregulation of c-Myc and Bcl-2