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This intricate pathway is crucial for maintaining cellular balance, and dysregulation can contribute to a myriad of diseases, including cancer, fibrosis, and immune disorders

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The characteristic hypermethylation within promoter regions of colorectal cancer tumor suppressor genes indicates that the epigenome likely plays a key role in mediating non-genetic sequence modifications driving malignant phenotype (182)

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When B12 is deficient, then melanin is produced at a slow rate, hence the skin becomes spotted or patchy

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While CGRP is most known clinically as a target for migraine treatment (anti-CGRP antibodies are major migraine drugs), its role in bone metabolism is increasingly recognized

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Aging 34 , 15641580 (2013)

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