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For all tests, a P -value lower than 0.05 was considered to indicate statistical significance

This suggests that Nedd4L plays a mediatory but not exclusive role in the downregulation of GLT-1 following ischemic injury

For example, the deletion of tumor suppressor genes, such as PTEN and P53 or the activation of tumor genes, such as c-Myc and Ras, may induce changes in nutrient supply, metabolic enzymes, metabolic requirements and many other metabolic characteristics

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These data indicate that Gal3 has a negative effect on the activation of PKR and eIF2, thereby affecting SG formation during lysosomal damage

Altogether, these findings suggest that Alox15-derived bioactive lipid expression needs to be tightly regulated and precisely coordinated