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1 Introduction Acute respiratory distress syndrome (ARDS) is a severe, life-threatening inflammatory condition of the lungs commonly triggered by infections such as bacterial pneumonia, viral pathogens (e.g., influenza and SARS-CoV-2), and systemic sepsis ( The pathogenesis of ARDS involves an exaggerated immune response that damages alveolar structures, disrupts the alveolar-capillary barrier, and promotes excessive inflammation, vascular leakage, and oxygenation failure ( Regulated cell death pathways, such as apoptosis, pyroptosis, necroptosis, and ferroptosis, play pivotal roles in controlling inflammation and maintaining tissue integrity

When taken as a supplement, NAC boosts the production of glutathione in the body, indirectly enhancing the bodys ability to neutralize harmful free radicals and support overall detoxification

Nearly 20 agents and extracts, including iron chelators and transporter, antioxidants, pharmacodynamic element from traditional Chinese medicine (TCM), ferroptosis-related protein inhibitors, and neuroprotective agent that inhibit ferroptosis have been reported to have a remissioning effect on retinal disease in animal models (Table 2

Combination therapy using PARP and ATR inhibitors has shown promising results in clinical trials, particularly in platinum-resistant HGSOC patients (127)

Glutathione also helps to protect against DNA damage and is necessary for supporting the immune system and is required for replication of the Lymphocyte immune cells

Chiang N, Serhan CN