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Chemotherapeutics causing CIPN likely have direct toxic effects on axonsevidenced by a lack of effect on axon integrity when applied to neuronal cell bodies under compartmentalized culturing conditions (Yang et al., 2009)although indirect effects due to altered gene expression cannot be ruled out

At the wound site, NO inhibits microbial activity by depleting glutathione in bacteria, enhancing type 1 collagen deposition, diminishing type 3 collagen and suppressing matrix metallopeptidase-9 expression, which is integral for wound healing

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