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The interstitial glucose values were measured at 15 min intervals by the CGM system ( 2.4 Endpoints The primary endpoint was TIR, the percentage of time spent in target range (3.910.0 mmol/L) during the last 2 weeks of treatment (weeks 2224), as recommended from the International CGM Consensus (2019) ( Because the safety profiles of PEG-Loxe and insulin glargine are well characterized, reportable adverse events (AEs) were limited to serious AEs (SAEs), AEs leading to discontinuation of trial drugs, and severe hypoglycemia (requiring assistance from another person)

mansoni , which has been studied extensively in this area, produces numerous serine proteases, which are expelled from its acetabular glands during penetration ( Figure 2A )

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