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Notably, both hyperandrogenemia and chronic low-grade inflammation can modulate DNA methyltransferase (DNMT) activity, leading to aberrant methylation of the AMH promoter in granulosa cells and subsequent impairment of folliculogenesis in PCOS (50)

Moreover, the application of a targeted FFA4 agonist resulted in substantial alleviation of IMQ-triggered psoriasis-like skin aberrations and inhibited the transition of CD4+ T cells into Th17 cells (43)

Chemiluminescent detection was performed using primary anti-COX4 (1:1000), anti-NRF-1 (1:1000) antibodies and the respective secondary anti-mouse IgG (1:5000) and anti-rabbit IgG (1:5000) antibodies, both bound to peroxidase

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Sci Rep 8 , 14325