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It has been demonstrated that GBM cells require exogenous methionine for their proliferation, invasion, and treatment resistance [100]

Zhou, N, Leung, CH, William Jr, WN, Weissferdt, A, Pataer, A, Godoy, M, Carter, B, Fossella, FV, Tsao, A, Blumenschein, GR, Le, X, Zhang, J, Skoulidis, F, Kurie, JM, Altan, M, Lu, C, Glisson, BS, Byers, LA, Elamin, YY, Mehran, RJ, Rice, DC, Walsh, GL, Hofstetter, WL, Roth, JA , Tran, HT, Wu, J, Solis Soto, LM, Kadara, HN, Swisher, SG, Vaporciyan, AA, Gibbons, DL, Lin, HY, Jack Lee, J, Heymach, JV, Vailati Negrao, M, Sepesi, B, Cascone, T

This cytotoxic process, however, is frequently counteracted by resistance mechanisms such as impaired uptake via the reduced folate carrier, DHFR gene amplification, and diminished polyglutamylation, which collectively reduce the intracellular levels of active drug

Immunol Volume

Health Canada, 2024

Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies