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Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells

Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E

Seeding was identical to that for mouse organoids (see below)

The molecule consists of a corrin ring coordinated to a central cobalt ion with a cyano ligand at the upper axial position and a 5,6-dimethylbenzimidazole nucleotide at the lower axial position

This vulnerability to antigen invasion and water loss is further exacerbated by the downregulation of filaggrin, a protein pivotal to skin barrier integrity, with genetic mutations influencing its activity