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All of the animal experimentation work of this study was made at the Firat University Experimental Animals Research Institute (FUDAM), meeting date November 27, 2019, protocol number 2019-141, meeting number 2019-22, decision number: 222

Universidad de Buenos Aires

Topical treatments include topical steroids, topical calcineurin inhibitors (such as tacrolimus or pimecrolimus), and topical vitamin D analogs (such as calcipotriene)

Tumor-educated macrophages (TEM) present alterations in polyamines, lipid metabolism, and adenosine accumulation

Pathologically, -Syn is subjected to a conformational change from -helical state to -sheet-rich oligomers and fibrils capable of aggregation due to mutations in its encoding gene SNCA, altering SNCA gene transcription and mRNA stability or processing (Nalls et al., 2019

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