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Notably, the ROS-induced NFkB response is multi-faceted since it can activate the expression of both antioxidant proteins, including MnSOD, Cu/ZnSOD, CAT 52 , 54 - 57

Studies find that oral glutathione supplementation can help improve skin elasticity and decrease signs of skin aging including dark spots

These experiments showed that NAPQI-induced cell death was reduced by increased GPx3 expression and was enhanced by decreased GPx3 expression, suggesting a crucial role for intracellular GPx in preventing the oxidative stress induced by NAPQI

Wu S, Wang Q, Du J, Zhu L, Yang F, Lu J, Li X, Li Y, Cui J, Miao Y

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