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The lack of a standardized normalization method in microarray techniques, along with the poor correlation between altered miRNA expression profiles and their functionality in cancer as shown in functional assays, necessitates a more precise method to link miRNA with cancer prognosis (180, 181)

doi: 10.1038/s41586-024-07251-0 48 GuoJ.LiL.CaiY.KangY

Free SH groups as in reduced GSH, are essential for the activity of all metabolite carriers in the inner mitochondrial membrane, otherwise, extensive thiol oxidation results in: the inhibition of transport activity, and the dissipation of the mitochondrial inner transmembrane potential ( [ ]), an early, potentially reversible event observed in mitochondrial related apoptotic processes, bioenergetic failure, also an early event that is part of the dissipation of [ ], and an increase in the permeability of the mitochondrial membrane, a later event in mitochondrial related apoptotic processes

doi: 10.1016/j.bbr.2009.10.011

IGF-1 is best considered to be a maturation hormone because of its apparent influence in cell proliferation, differentiation, and maturation, helping them to carry out their specialized functions

doi: 10.34067/KID.0006792020 113 OnalE