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NAD + is also involved in metabolic switching, or the Warburg effect, in which the main source of energy production is anaerobic glycolysis through fermentation of pyruvate to lactic acid, as opposed to mitochondrial oxidative phosphorylation 340

187 In another controlled trial in stroke patients with a history of DVT, lowering high homocysteine levels using folic acid and B12 was shown to reduce the rate of DVT recurrence from 28.9% to 4.4%

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