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Future Direction and Call to Action The current evidence gap presents an opportunity for orthopaedic investigators to establish high-quality prospective registries evaluating peptide exposure in real-world musculoskeletal populations

Potential conflicts of interest: Dr Culpepper has served as an advisor to or consultant for Boehringer-Ingelheim, Forest, Janssen, Jazz, H

Safe, effective use of peptide therapy requires appropriate dosing, administration, and monitoring as well as sourcing from reputable manufacturers

Indeed, there is currently no evidence from randomised controlled trials assessing the effects of dietary supplementation with vitamin B12 on peripheral and central nerve conduction and neurosensory processing

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The protein sequence was assigned to mouse TUBA1A (Uniprot P68369) and TUBB3 (Uniprot Q9ERD7), respectively, as they are the most prominent isotypes in brain tissue and provided the best fit