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Baclofen is primarily used to treat muscle spasticity, while benzodiazepines are mainly prescribed for anxiety, seizures, and sleep disorders

Xing, et al

Mar 14 2020;18(1):22

Nature 457:475479 Sjstrm PJ, Rancz EA, Roth A et al (2008) Dendritic excitability and synaptic plasticity

Ferroptosis (iron-dependent lipid peroxidation) is also implicated as a mechanistic bridge by emerging evidence: GPX4 dysfunction and iron accumulation increase lipid peroxides, which sensitize neurons to ferroptotic death and provide extra DAMP-like signals that increase inflammasome activation [58, 59]