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Exploratory pooled brain metastases analyses from DESTINY-Lung01 and DESTINY-Lung02 presented at European Society for Medical Oncology (ESMO) 2023, demonstrated intracranial (IC) efficacy of T-DXd, with IC-ORR of 50% and 30% and median IC-DoR of 9.5 months and 4.4 months, for 5.4 mg/kg and 6.4 mg/kg Q3W schedules, respectively

Taken together, the evidence suggests that natural products and herbal formulations represent valuable therapeutic resources for GI health

25 Thus, while autophagy is clearly protective under physiological and early stress conditions, its chronic hyperactivation may become maladaptive

Therefore, targeting lncRNAs that regulate ferroptosis may offer novel strategies to enhance chemotherapy responses and overcome drug resistance in NSCLC

TLR2 also induces the anti-tumor M1-like macrophage polarization (66)

Additionally, ROS can activate the cAMP pathway and its downstream signaling cascade, which is important for sperm capacitation and forward movement [41, 43, 45, 46]