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SERMs are non-steroidal estradiol analogs with mixed agonist-antagonist effects on ERs and are used in osteoporosis and breast cancer treatment (Jordan, 2004)

The 50100mg daily dose range was derived from rodent models where 10mg/kg bodyweight produced measurable NNMT suppression without toxicity across 12-week administration periods

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Epub 2010 Sep 5

Color of labels indicate tissues that are prone (pancreas, colon, stomach

If suspicion of a CMCD is high (clonality prediction score 2), the criterion standard for diagnosing SM or MMAS is a bone marrow biopsy, which should ideally be performed in a center with expertise in SM since the burden of abnormal mast cells is typically quite low in those patients [49, 55, 65]