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The mechanisms by which peptides exert their therapeutic effects are diverse, ranging from hormone replacement and receptor modulation to enzyme inhibition, direct cellular interactions, and tissue repair processes

The novelty of this review lies in its integrative approach, moving beyond a mere description of disparate pathways to synthesize a coherent framework that connects key metabolic nodessuch as the mammalian target of rapamycin (mTOR)-hypoxia-inducible factor 1-alpha (HIF-1)-glycolysis axis, AMP-activated protein kinase (AMPK)-FAO signalinginto a dynamic immunometabolic network ( Figure 1 )

These nanoparticles encapsulate polyphenols within their matrix or adsorb them onto their surface, protecting them from degradation and allowing for efficient mucosal penetration ( P

References: [1] GANG LIU

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Salviolone, a bisnorditerpene compound derived from Salvia miltiorrhiza and Salvia paramiltiorrhiza, has been shown to have inhibitory effects on melanoma cells by inhibiting matrix metalloproteinase 2 activity and the STAT3 pathway [41]