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Biochemistry of peroxisomes in health and disease

Gonzalez- Rivas PA, Chambers M, Liu J

Advanced tools, including in vivo autophagy/mitophagy reporters, high-resolution mitochondrial imaging, and integrative multi-omics, are needed to resolve these discrepancies and identify key downstream mediators such as NLRP3, the Nur77-IDH1 axis, and regulators of ferroptosis and pyroptosis

The delivery of NPTAs into the brain mostly depends on active transport mechanisms, including as receptor-mediated transcytosis, and carrier-mediated transcytosis