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Reference: 18.4ea71002.1784956993.5f327053

Clinical trials indicate that IVC does not adversely interfere with chemotherapy and pre-clinical studies indicate that it may in fact act synergistically in combination with different chemotherapeutic agents

Mitchell KG, Ikoma N, Nelson DB, Maru DM, Erasmus JJ, Weston BR, Vaporciyan AA, Antonoff MB , Mehran RJ, Rice DC, Roth JA, Swisher SG, Sepesi B, Walsh GL, Correa AM, Das P, Blum MA, Badgwell BD, Hofstetter WL

As the damage to the membrane structure and organelles increases, a new wave of ROS and inflammatory factors further feedback into the pathways of ferroptosis and necroptosis, amplifying their effects

And a recent research shown that DNA polymerase gamma deficiency induced mtROS increasing which promotes RICTOR expression to trigger pro-survival autophagy [74]