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Therapeutic agents are steroids or antiemetics administered via intravenous infusion

Subgroup analysis of those subjects having reduced corneal nerve fibers, and therefore more definitive evidence of small fiber neuropathy (37), show that ARA 290 treatment is associated with an increase in corneal nerve fiber density, analogous to the improvement seen after improved metabolic control (42) and after simultaneous pancreas and kidney transplantation (43)

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At 2mg/mL, the amount is pharmacologically modest and is not expected to produce systemic niacinamide effects

In addition to demonstrating KL1s activity in THP-1-derived human macrophages and primary human neutrophils, we further examined whether macrophages derived from human peripheral blood mononuclear cells (PBMCs) could recapitulate the response